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Updated: Jan 7, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
When Fitness Turns Fatal: A Case of Severe Rhabdomyolysis in a 20-Year-Old Male
Wardah Tariq1, Habeeb Kamal1, Aung M Naing1
1General Medicine, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Abstract:
Exertional rhabdomyolysis (ER) is a potentially life-threatening condition caused by intense or prolonged physical activity, leading to skeletal muscle injury and leakage of intracellular components into the circulation. Although commonly recognized in athletes and military recruits, it may also occur in previously healthy individuals undertaking unaccustomed high-intensity exercise. We report a 20-year-old male with no significant medical history who presented with muscle soreness, dysuria, and dark urine following increased gym activity. Laboratory studies demonstrated extremely elevated creatine kinase (CK) levels consistent with severe ER; however, kidney function remained entirely normal despite the markedly elevated CK, a feature that makes this case clinically distinctive. Prompt recognition and aggressive intravenous fluid resuscitation resulted in full recovery. This case provides educational value by emphasizing that even "sky-high" CK levels do not invariably lead to renal impairment when ER is rapidly identified and managed, underscoring the importance of early intervention and careful monitoring in individuals engaging in unsupervised intense exercise.
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