Biological Reference Values for Newborn Screening Parameters in Accordance to Gestational Age and Birth Weight- A Prospective Study
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View abstract on PubMed
Summary
This summary is machine-generated.This study establishes crucial reference values for newborn screening (NBS) parameters, differentiating between preterm (PT) and term-born infants, and low-birth weight (LBW) and normal-birth weight (NBW) newborns. These findings aid in accurate diagnosis and improved health outcomes for diverse infant populations.
Area Of Science
- Neonatal Medicine
- Biomarker Discovery
- Metabolic Disorders
Background
- Metabolic differences exist between preterm (PT) and term-born (NBW) newborns.
- Accurate diagnostic biomarkers are essential for timely disorder detection and improved health outcomes.
- Establishing group-specific reference values considering gestational age and birth weight is critical.
Purpose Of The Study
- To compare newborn screening (NBS) parameters across different gestational age and birth weight groups.
- To establish dedicated reference values for NBS parameters in term-normal birth weight (TERMNBW), term-low birth weight (TERMLBW), preterm-normal birth weight (PTNBW), and preterm-low birth weight (PTLBW) newborns.
- To identify sex-based differences in NBS marker levels.
Main Methods
- A prospective study involving 2860 newborns undergoing NBS in dried-blood spot samples within five days of birth.
- Categorization of newborns into four groups: TERMNBW, TERMLBW, PTNBW, and PTLBW.
- Analysis of central tendency measures and comparison of NBS parameters across study groups.
Main Results
- Sex-based differences observed: higher n17-OHP in males; higher nIRT and nMSUD in females.
- nTSH levels were higher in TERMNBW compared to PTLBW.
- n17-OHP levels were lower in TERMNBW and TERMLBW compared to PTNBW and PTLBW.
- Highest nBIOT and nG6PD ranges were found in TERMNBW.
- Established reference values for nTSH, n17-OHP, nIRT, nG6PD, and nBIOT for TERMNBW and PTLBW groups.
- Similar reference values noted for nPKU, nGAL, and nMSUD across groups.
Conclusions
- The study provides a comprehensive comparison of NBS parameters across distinct newborn subgroups.
- Detailed reference levels are established, accounting for gestational age and birth weight.
- These findings support the development of tailored diagnostic criteria for diverse neonatal populations.
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