Related Experiment Video
Updated: Jan 7, 2026
10:37
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
8.6K
Identification and validation of biomarkers related to centrosome replication in ulcerative colitis based on bulk
Zhenhuan Yang1, Xingxing Wu1, Lei Luo1
1Department of Gastroenterology, Henan Provincial Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine), Zhengzhou, Henan, China.
Frontiers in Immunology
|December 29, 2025
Summary
Six centrosome amplification-related genes (CARGs) were identified as potential biomarkers for ulcerative colitis (UC). These genes, including TEX11 and SLC16A1, show significant implications in UC pathogenesis and immune cell interactions.
Area of Science:
- Genetics and Molecular Biology
- Gastroenterology
- Immunology
Background:
- Ulcerative colitis (UC) is a chronic inflammatory condition with unclear pathogenesis.
- Centrosome amplification (CA) is implicated in UC, but its specific role requires elucidation.
Purpose of the Study:
- To investigate the relevance of centrosome amplification-related genes (CARGs) in UC progression.
- To identify potential biomarkers for UC using machine learning and expression validation.
Main Methods:
- Differential gene expression analysis of UC and control samples.
- Biomarker identification using 11 machine learning algorithms and ROC analysis.
- Functional enrichment, immune infiltration, and single-cell expression analyses.
Main Results:
- Six CARGs (TEX11, SLC16A1, OVOL1, EDNRA, HEPACAM2, SPIRE2) identified as potential UC biomarkers.
- Biomarkers associated with cell adhesion molecules, oxidative phosphorylation, and immune cell infiltration (neutrophils, macrophages).
- Validation confirmed differential expression of key biomarkers in UC colonic mucosa.
Conclusions:
- Identified CARGs serve as potential biomarkers for UC pathogenesis.
- These biomarkers are linked to immune cell interactions and specific cellular pathways in UC.
- Further research into these CARGs may reveal novel therapeutic targets for UC.
