Related Experiment Video

Updated: Jan 7, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.4K

Invasively measured aortic pulse pressure and long-term prognosis in patients undergoing invasive coronary

Hack-Lyoung Kim1, Soonil Kwon, Hyun Sung Joh

  • 1Division of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.

Journal of Hypertension
|December 29, 2025
PubMed

Insights

Invasive aortic pulse pressure (aPP) measured during coronary angiography predicts long-term cardiovascular events. Higher aPP indicates increased risk, offering a valuable tool for risk assessment in high-risk patients.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Clinical Risk Assessment

Background:

  • Invasive intra-arterial pressure measurement is the gold standard but not practical for routine use.
  • Aortic pulse pressure (aPP) is a potential non-invasive marker, but its prognostic value requires further investigation.
  • This study focuses on the prognostic significance of invasively measured aPP in patients undergoing invasive coronary angiography (ICA).

Purpose of the Study:

  • To evaluate the prognostic value of invasively measured aortic pulse pressure (aPP).
  • To determine if aPP can predict major adverse cardiovascular events (MACE) in patients undergoing invasive coronary angiography (ICA).
  • To assess the utility of aPP as a risk stratification tool in a high-risk cardiovascular population.

Main Methods:

  • Prospective enrollment of 1110 patients undergoing ICA (mean age 65 years, 35.5% female).
  • Aortic pressures were measured invasively using a pigtail catheter just before ICA.
  • Major adverse cardiovascular events (MACE) were tracked during a median follow-up of 6.3 years.

Main Results:

  • A total of 153 MACE (13.8%) occurred during follow-up.
  • Patients with MACE exhibited significantly higher aPP (83.0 ± 25.3 mmHg) compared to those without (62.9 ± 18.1 mmHg; P < 0.001).
  • Higher aPP (≥78 mmHg) was linked to increased MACE risk (log-rank P < 0.001), and each 10 mmHg increase in aPP raised MACE risk by 68% (HR 1.68; P < 0.001) after adjustment.

Conclusions:

  • Invasively measured aPP is a potent and independent predictor of long-term cardiovascular outcomes in patients undergoing ICA.
  • aPP can serve as a valuable addition to existing risk assessment strategies for this patient group.
  • These findings highlight the clinical relevance of aPP in managing high-risk cardiovascular patients.
Abstract

Keywords:
aortic pulse pressurecardiac catheterizationcoronary artery diseasemajor adverse cardiac eventsprognosis

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.8K
Myocardial Infarction and Functional Outcome Assessment in Pigs12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.6K

Related Concept Videos

Sites for measruring blood pressure01:21

Sites for measruring blood pressure

Blood pressure measurement is a fundamental clinical procedure, providing crucial data for assessing cardiovascular health. Among the various sites for this measurement, the brachial and popliteal arteries are predominantly utilized due to their accessibility and the reliability of their readings. This lesson delves into the anatomical significance, methodology, and considerations of measuring blood pressure at these locations.
The Brachial Artery: Primary Site for Blood Pressure Measurement
3.2K
Assessment of blood pressure in brachial artery(two-step method)01:23

Assessment of blood pressure in brachial artery(two-step method)

Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...
1.4K
Measurement of Blood Pressure01:17

Measurement of Blood Pressure

Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
2.6K
Blood Pressure01:24

Blood Pressure

The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
9.3K
Pulse01:16

Pulse

When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical...
1.9K
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
366