Kupffer cells control neonatal hepatic metabolism via Igf1 signaling
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View abstract on PubMed
Summary
This summary is machine-generated.Yolk sac-derived Kupffer cells (KCs) are crucial for neonatal liver metabolism, regulating glycogen storage and energy supply. These macrophages produce insulin-like growth factor 1 (Igf1), essential for newborn energy balance.
Area Of Science
- Hepatology
- Immunology
- Developmental Biology
Background
- Neonatal liver metabolism is vital for energy supply, primarily through glycogen storage and glucose mobilization.
- Systemic hormones like insulin and glucagon are believed to regulate these metabolic processes.
- The influence of liver-resident macrophages, Kupffer cells (KCs), on neonatal hepatocyte metabolism is largely unknown.
Purpose Of The Study
- To investigate the role of Kupffer cells in regulating neonatal hepatocyte metabolism.
- To determine if yolk sac-derived KCs influence glycogen storage and energy supply in newborns.
- To identify potential local factors produced by KCs that regulate neonatal liver function.
Main Methods
- Utilized conditional knockout mouse models to specifically target and deplete yolk sac-derived Kupffer cells.
- Assessed hepatic glycogen storage and mobilization in newborn pups lacking these specific KCs.
- Analyzed the regulation of the tricarboxylic acid cycle and insulin-like growth factor 1 (Igf1) production.
Main Results
- Newborn pups lacking yolk sac-derived KCs exhibited accelerated glycogen mobilization.
- Yolk sac-derived KCs regulate hepatocyte function by influencing the tricarboxylic acid cycle.
- These KCs were identified as a major source of local Igf1 production, crucial for metabolic balance.
Conclusions
- Yolk sac-derived Kupffer cells are essential for maintaining neonatal hepatocyte glycogen storage and metabolic homeostasis.
- Monocyte-derived KC-like cells cannot compensate for the loss of yolk sac-derived KCs in this role.
- Local Igf1 production by Kupffer cells is critical for regulating energy metabolism in newborns.
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