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Updated: Jan 7, 2026
Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
Published on: March 5, 2019
Stereocontrol on Helical Bimetallic DNA Catalysts with Switchable Enantioselectivity via Dynamic Reaction Distance
Jie Sheng1,2, Kelly Kar Yun Koh1, Zihan Li3
1Department of Chemistry, National University of Singapore; Singapore 117544, Singapore.
Abstract:
Bimetallic centers, found in some metalloenzymes and synthetic small-molecule catalysts, offer unique catalytic features arising from proximal and appropriately positioned two metal centers. However, the integration of such dual-metal centers into a highly programmable DNA scaffold for asymmetric catalysis remains unexplored. Herein, we introduce a new mode of stereocontrol enabled by bimetallic DNA catalysts. Diverging from traditional steric-induced stereocontrol, our approach leverages dynamic regulation of the spatial relationship between two metal-binding substrates to dictate stereoselectivity. By modulating the intermetallic distance and orientation, we achieve complete reversal of enantioselectivity, allowing access to both enantiomers of 1,5-dicarbonyl compounds with vicinal chiral centers.
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