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Evolution in the targets for blood pressure treatment

Paul K Whelton1,2, Samantha O'Connell1, Katherine Mills1

  • 1Department of Epidemiology, Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine.

Current Opinion in Nephrology and Hypertension
|December 29, 2025
PubMed
Abstract

Insights

New therapies for hypertension show promise in lowering blood pressure and preventing cardiovascular disease. However, high blood pressure remains a global health challenge requiring improved control strategies.

Area of Science:

  • Cardiology
  • Public Health
  • Hypertension Management

Background:

  • Hypertension is a major global health concern with persistently poor control rates worldwide.
  • Recent advancements offer new avenues for blood pressure management and cardiovascular disease prevention.

Purpose of the Study:

  • To review novel nonpharmacological and pharmacological therapies for lowering blood pressure.
  • To examine current hypertension treatment goals and strategies for enhancing hypertension control.

Main Methods:

  • Systematic review of clinical trials and cohort studies on blood pressure management.
  • Analysis of evidence for nonpharmacological interventions like diet, exercise, and stress reduction.
  • Evaluation of pharmacological approaches including single pill combinations and treatment targets.

Main Results:

  • Salt substitutes and specific exercises (isometric resistance, weekend warrior) effectively lower blood pressure.
  • Continuous association between alcohol intake and blood pressure suggests no safe consumption level.
  • Effective strategies for improved hypertension control include team-based management, health coaching, and home blood pressure monitoring.
  • Lower systolic blood pressure targets (<130 and <120 mmHg) are linked to reduced cardiovascular disease and mortality.

Conclusions:

  • Despite new knowledge, hypertension control remains inadequate globally.
  • There is a critical need to enhance prevention, detection, treatment, and overall management of high blood pressure.
Keywords:
antihypertensive treatmentblood pressurehypertension

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