Comparison meta-analysis of two swept-source optical coherence biometers

This systematic review and meta-analysis aims to evaluate the comparability of two swept-source optical coherence tomography (SS-OCT) biometers, Anterion and IOLMaster 700. This systematic review and meta-analysis reviewed articles published until October 1, 2023. Eligibility criteria included a comparative study design, absence of ocular diseases except cataract or refractive errors, same day measurements with both devices, and outcomes such as axial length (AL), mean keratometry, astigmatism vectors, anterior chamber depth (ACD), central corneal thickness, lens thickness (LT), corneal diameter, white-to-white (WTW), and intraocular lens (IOL) power for emmetropia. This systematic review incorporated 17 studies (2943 eyes). The mean difference of AL measurements obtained with Anterion and IOLMaster 700 was -0.01 [-0.09; 0.06]. Anterion provided a significantly larger ACD (0.10 mm [0.08-0.12 mm]) and LT (0.04 mm [0.01; 0.07]), while IOLMaster 700 had significantly larger WTW measurements (0.20 mm [-0.24; -0.16]). Corneal measurements tend to be flatter for Anterion, although no significant differences were found between devices. In conclusion, this meta-analysis showed statistically significant differences in WTW, LT, and ACD measurements between devices. AL measurements were comparable between biometers. Anterior mean and steep and flat keratometry tend to be higher with IOLMaster700. These differences may result in a higher IOL power for emmetropia when data are entered from Anterion measurements. Future studies will be needed to establish the influence of these differences on the refractive predictability of IOL power calculation.