Comparison meta-analysis of two swept-source optical coherence biometers

Area of Science:

• Ophthalmology
• Biomedical Engineering
• Medical Imaging

Background:

• Accurate biometry is crucial for intraocular lens (IOL) power calculation.
• Swept-source optical coherence tomography (SS-OCT) biometers offer advanced measurement capabilities.
• Comparing different SS-OCT devices is essential for clinical practice standardization.

Purpose of the Study:

• To systematically review and meta-analyze the comparability of Anterion and IOLMaster 700 SS-OCT biometers.
• To evaluate differences in key ocular biometric parameters measured by these devices.
• To assess the potential impact of measurement discrepancies on IOL power calculations.

Main Methods:

• Systematic review and meta-analysis of comparative studies published until October 1, 2023.
• Inclusion of 17 studies involving 2943 eyes with cataract or refractive errors.
• Analysis of axial length, keratometry, anterior chamber depth, lens thickness, and white-to-white measurements.

Main Results:

• Axial length measurements were comparable between Anterion and IOLMaster 700 (mean difference -0.01 mm).
• Anterion showed significantly larger anterior chamber depth and lens thickness.
• IOLMaster 700 yielded significantly larger white-to-white measurements; keratometry tended to be higher.

Conclusions:

• While axial length measurements are comparable, significant differences exist in other parameters between Anterion and IOLMaster 700.
• These biometric differences may necessitate adjustments in IOL power calculations when using Anterion data.
• Further research is needed to determine the clinical impact on refractive predictability.