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Updated: May 6, 2026

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
Published on: June 3, 2021
Computational fluid dynamics analysis of hemodynamic characteristics in aortic dissection induced by intramural
Kun Liu1, Shanlin Qin2, Zhifu Huan3
1Department of Cardiac Surgery, The University of Hong Kong-Shenzhen Hospital, Futian District, Shenzhen, Guangdong, China.
Abstract:
In this study, two case models of intramural hematoma (IMH) progressing to aortic dissection were analyzed using computational fluid dynamics, with a focus on the hemodynamic characteristics before and after the dissection. In the initial IMH model, disturbed flows were observed during the early and late phases of contraction within the aortic arch and regions of significant vascular curvature. Furthermore, the IMH models also revealed extensive areas of low time-averaged wall shear stress (TAWSS), high oscillatory shear index (OSI), and high endothelial cell activation potential (ECAP) values, particularly on the lesser-curvature side of the aortic arch. Regions with low TAWSS, high OSI, and high ECAP in IMH cases can be identified as potential high-risk areas for disease progression to aortic dissection.
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