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Published on: February 28, 2019
Adamantinoma-like Ewing sarcoma with NRAS Q61R mutation-a hitherto unreported mutation in a case from the nasal
Bingcheng Wu1, Xinyi Qu1, Yi Ting Lai1
1Department of Pathology, National University Hospital, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore.
Abstract:
Adamantinoma-like Ewing sarcoma (ALES) is a rare malignant neoplasm currently classified as a subtype of Ewing sarcoma (ES) and is similarly molecularly defined by a FET-ETS translocation. However, ALES demonstrates some morphologic and immunohistochemical features distinct from conventional ES. In this case report, we present the clinico-pathological features of a case of ALES in the nasal septum of a 75-year-old lady, with a hitherto unreported NRAS Q61R mutation. Further studies are required to investigate the prevalence and clinical significance of the NRAS Q61R mutation in ALES.
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