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A histone acetylation score for prognostic stratification and immunogenomic profiling in esophageal cancer

Chanyuan Fan1, Kailun Sun2, Zhaoyan Feng1

  • 1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Qiaokou District, Wuhan, 430030, Hubei, People's Republic of China.

Discover Oncology
|December 29, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Esophageal cancerHistone acetylationImmunogenomic profilingPrognosis

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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