Deep Learning-Based Continuous QT Monitoring to Identify High-Risk Prolongation Events After Class III Antiarrhythmic...

Drug-induced QT prolongation after successful inpatient loading of class III antiarrhythmics may occur during routine outpatient care. Insertable cardiac monitors offer continuous signals but are limited by single-lead configuration. We hypothesized that a spatially aware deep learning system (3DRECON-QT) can reconstruct spatial information from a single lead vector to quantify QT/QTc and identify high-risk prolongation.

We developed 3DRECON-QT using a multitask encoder-decoder that ingests a 10-s single-lead signal, reconstructs 12 leads, and predicts QT/QTc. The model was developed using 12-lead ECGs with clinician-adjudicated QT/RR from a large health system and tested in an external center with different ECG hardware. Continuous monitoring performance was assessed in a public dofetilide-loading data set with serial ECGs. In a real-world cohort of outpatients on dofetilide or sotalol presenting to the hospital or emergency room for any reason, rates of ventricular arrhythmias and QT prolongation were assessed. Device validation was tested in patients with insertable cardiac monitor recordings paired with clinical 12-lead ECGs.

3DRECON-QT classified prolonged QTc from single-lead signals with area under the receiver operating characteristics curve, 0.942 (mean absolute error, 17.5 ms) in the internal test set and 0.943 (mean absolute error, 21.1 ms) externally. During continuous dofetilide monitoring, predictions correlated with ground truth (r, 0.851; mean absolute error, 17.8 ms; area under the receiver operating characteristics curve, 0.936 for prolonged QTc, 0.816 for ≥15% QTc rise). QTc prediction from true insertable cardiac monitor recordings showed r=0.824 and mean absolute error, 17.5 ms. In outpatients on class III antiarrhythmics (n=1676), 16.5% had high-risk QTc prolongation. Ventricular arrhythmia events were 3.97% versus 0.86% without prolongation (adjusted odds ratio, 4.24 [95% CI, 1.81-9.90]). 3DRECON-QT detected these events with area under the receiver operating characteristics curve 0.94 (F1 score, 0.60).

A single-lead, deep-learning approach can achieve guideline-level measurement accuracy, enable continuous QTc surveillance from nonstandard ECG vectors, and identify clinically meaningful outpatient QTc prolongation associated with a >4-fold increase in serious ventricular arrhythmias. This strategy may enhance safety monitoring after class III antiarrhythmic initiation and support targeted intervention.