Related Experiment Video
Updated: Jan 7, 2026
14:58
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
10.1K
KRAS Footprints in the Skin: Leveraging Targeted Therapy for Unresectable Intra-Cerebral AVM
Donglin Zhang1, Jennifer M Kwon2, Beverly Aagaard-Kienitz3
1Department of Dermatology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA.
Pediatric Dermatology
|December 29, 2025
Summary
A lipomatous scalp nodule biopsy identified a KRAS variant in a patient with an unresectable brain arteriovenous malformation (AVM). This finding highlights the diagnostic utility of skin biopsies for complex vascular anomalies.
Area of Science:
- Neurology
- Genetics
- Dermatology
Background:
- Intracerebral arteriovenous malformations (AVMs) can be unresectable, posing significant diagnostic and therapeutic challenges.
- Molecular characterization of brain AVMs is crucial for targeted therapy but often limited by lesion inaccessibility.
