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Management and Outcomes of Glaucoma in Children with Stickler Syndrome

Adam Jacobson1, Safa Rahmani2, Brenda L Bohnsack2

  • 1Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan.

Ophthalmology. Glaucoma
|December 29, 2025
PubMed

Insights

Glaucoma affects 14% of children with Stickler syndrome. Infantile glaucoma requires drainage devices, while post-surgery glaucoma may need medication or surgery, impacting vision.

Area of Science:

  • Ophthalmology
  • Genetics
  • Pediatrics

Background:

  • Stickler syndrome is a genetic disorder affecting connective tissues.
  • Ocular manifestations are common in Stickler syndrome, including glaucoma.
  • Early diagnosis and management are crucial for preserving vision.

Purpose of the Study:

  • To assess the prevalence, management, and outcomes of glaucoma in pediatric patients with Stickler syndrome.
  • To identify risk factors and specific glaucoma subtypes within this population.
  • To evaluate the effectiveness of different treatment strategies.

Main Methods:

  • Retrospective observational case series of 97 children diagnosed with Stickler syndrome.
  • Data collected included ocular examinations, genetic information, glaucoma diagnoses, and surgical history.
  • Analysis focused on best-corrected visual acuity (BCVA), glaucoma type, and surgical interventions.

Main Results:

  • 14% of patients with Stickler syndrome developed glaucoma.
  • Glaucomatous eyes were more myopic and had worse final BCVA.
  • Infantile-onset glaucoma (n=5) required glaucoma drainage devices (GDDs); post-intraocular surgery glaucoma (n=9) varied in management, with some needing GDDs.

Conclusions:

  • Glaucoma is a frequent complication in children with Stickler syndrome.
  • Infantile glaucoma management often necessitates angle bypass surgery for IOP control.
  • Post-surgical glaucoma may respond to medical therapy, but GDD placement can be complex due to prior ocular surgeries.
Abstract

Keywords:
Glaucoma following retinal detachmentInfantile-onset glaucomaPediatric glaucomaRetinal detachmentStickler syndrome

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