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The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
Stephen P H Alexander1, Doriano Fabbro2, Alasdair J Gibb3
1Division of Physiology, Pharmacology & Neuroscience, School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
British Journal of Pharmacology
|December 29, 2025
Summary
The Concise Guide to Pharmacology 2025/26 offers a curated overview of human drug targets and their interactions. This biennial publication provides expert recommendations for pharmacological tools, serving as a stable reference for drug discovery.
Area of Science:
- Pharmacology
- Drug Discovery
- Biochemistry
Background:
- The British Journal of Pharmacology publishes biennial updates to its Concise Guide to Pharmacology.
- The guide provides a comparative overview of drug target families, summarizing key pharmacological properties.
Purpose of the Study:
- To present the 2025/26 edition of the Concise Guide to Pharmacology.
- To offer a stable, citable, point-in-time record of human drug targets and interactions.
- To provide expert-curated recommendations for selective pharmacological tools.
Main Methods:
- Compilation of data on approximately 1900 human drug targets and 7000 interactions.
- Inclusion of information on nearly 4400 ligands.
- Expert curation and summarization of pharmacological properties and tool recommendations.
Main Results:
- The 2025/26 edition summarizes key pharmacological properties for ~1900 human drug targets and ~7000 interactions.
- It provides recommendations for 'Gold Standard' selective pharmacological tools.
- The guide is divided into six major target families: enzymes, G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, and transporters.
Conclusions:
- The Concise Guide to Pharmacology 2025/26 serves as a valuable, accessible resource for researchers.
- It complements the comprehensive online database at www.guidetopharmacology.org.
- This edition provides official IUPHAR classification and nomenclature for human drug targets where applicable.
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