Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Membrane Transporters01:31

Membrane Transporters

17.6K
Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
Transporters are mainly composed of alpha-helices, built from bundles of ten or more helices traversing the plasma membrane. The solute-binding sites are located midway, where some of the helices are broken or distorted, making space for the binding site through...
17.6K
Nonlinear Pharmacokinetics: Role of Transporters01:27

Nonlinear Pharmacokinetics: Role of Transporters

252
A drug's nonlinear kinetics can be influenced by a diverse range of transporter proteins that serve as crucial players in drug distribution. These transporters, found within cells, can enhance or reduce local drug concentrations by facilitating the influx or efflux of drugs. For instance, the expression of xenobiotic transporters can be influenced by factors such as age and gender, potentially impacting the linearity of drug response.
Polymorphisms occurring in drug transporters can alter...
252
The Significance of Membrane Transport01:44

The Significance of Membrane Transport

40.9K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
40.9K
Carrier-Mediated Transport01:06

Carrier-Mediated Transport

975
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
975
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

243
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
243
Hepatic Drug Clearance: Role of Transporters01:14

Hepatic Drug Clearance: Role of Transporters

277
In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
277

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infection-induced glucose starvation triggers NINJ1-dependent macrophage lysis and Candida escape.

Nature communications·2026
Same author

Discovery of a sulfotyrosine-motif in the human TrkB extracellular domain required for agonist activation.

bioRxiv : the preprint server for biology·2026
Same author

Activation of TREK-1 and TREK-2 Two-Pore Domain Potassium Channels by the K<sub>v</sub>4 Channel Modulator, NS5806.

Pharmacology research & perspectives·2026
Same author

Inhibition of purine nucleoside and nucleobase transporters by tyrosine kinase inhibitors.

PloS one·2026
Same author

Aminoacyl-tRNA Synthetases: Variant Classification, Functional Assays, and Emerging Therapeutic Strategies.

Journal of inherited metabolic disease·2026
Same author

Updated BJP guidelines for transparent and rigorous natural product research.

British journal of pharmacology·2026
Same journal

Fangchinoline alleviates hypertensive heart failure via PGC-1α/STAT6/PPARγ activation of mitophagy against ferroptosis.

British journal of pharmacology·2026
Same journal

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells.

British journal of pharmacology·2026
Same journal

Immune checkpoint inhibitor-induced arrhythmias: Mechanistic insights from clinical and preclinical studies.

British journal of pharmacology·2026
Same journal

Leflunomide-inhibited STAT1 activity ameliorates intramuscular M1 macrophage infiltration and promotes muscle regeneration in Duchenne muscular dystrophy.

British journal of pharmacology·2026
Same journal

Pharmacological activation of NO-cGMP signalling attenuates metabolic dysfunction-associated steatohepatitis.

British journal of pharmacology·2026
Same journal

Inhibition of kynurenine 3-monooxygenase (KMO) reduces fentanyl and sucrose intake and relapse-like behaviour in rats.

British journal of pharmacology·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Author Spotlight: Expression and Purification of Human Solute Carrier Transporters Using Codon-Optimized Genes
07:10

Author Spotlight: Expression and Purification of Human Solute Carrier Transporters Using Codon-Optimized Genes

Published on: September 29, 2023

4.3K

The Concise Guide to PHARMACOLOGY 2025/26: Transporters.

Stephen P H Alexander1, Alasdair J Gibb2, Eamonn Kelly3

  • 1Division of Physiology, Pharmacology & Neuroscience, School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.

British Journal of Pharmacology
|December 29, 2025
PubMed
Summary
This summary is machine-generated.

The Concise Guide to Pharmacology 2025/26 offers a stable, citable record of human drug targets and their interactions. This biennial publication provides expert-curated pharmacological tools and nomenclature, superseding previous editions.

More Related Videos

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

47.2K
Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane SSM-Based Electrophysiology
09:12

Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane SSM-Based Electrophysiology

Published on: May 3, 2021

2.9K

Related Experiment Videos

Last Updated: Jan 7, 2026

Author Spotlight: Expression and Purification of Human Solute Carrier Transporters Using Codon-Optimized Genes
07:10

Author Spotlight: Expression and Purification of Human Solute Carrier Transporters Using Codon-Optimized Genes

Published on: September 29, 2023

4.3K
Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

47.2K
Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane SSM-Based Electrophysiology
09:12

Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane SSM-Based Electrophysiology

Published on: May 3, 2021

2.9K

Area of Science:

  • Pharmacology
  • Drug Discovery
  • Biomedical Science

Background:

  • The British Journal of Pharmacology publishes biennial updates to its Concise Guide to Pharmacology.
  • The guide offers a comparative overview of drug target families, summarizing key pharmacological properties.

Purpose of the Study:

  • To provide a stable, citable, point-in-time record of human drug targets and their interactions.
  • To offer expert-curated recommendations of selective pharmacological tools for target identification.
  • To present official International Union of Basic and Clinical Pharmacology (NC-IUPHAR) classification and nomenclature for drug targets.

Main Methods:

  • Summarizing pharmacological properties of approximately 1900 human drug targets and nearly 7000 interactions.
  • Condensing detailed information from the www.guidetopharmacology.org website into a 500-page printed guide.
  • Dividing content into six major pharmacological target families: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes, and transporters.

Main Results:

  • The 2025/26 edition summarizes around 1900 human drug targets and nearly 7000 interactions.
  • It includes nomenclature guidance, concise summaries, information on pharmacological tools, key references, and further reading suggestions.
  • The guide serves as a permanent record, distinct from the continuously updated online database.

Conclusions:

  • The Concise Guide to Pharmacology 2025/26 is a valuable resource for researchers, providing a structured overview of drug targets and pharmacological tools.
  • It acts as a permanent, citable reference, complementing the comprehensive online database.
  • The publication ensures standardized nomenclature and recommendations for pharmacological research.