The Concise Guide to PHARMACOLOGY 2025/26: Transporters

Area of Science:

• Pharmacology
• Drug Discovery
• Biomedical Science

Background:

• The British Journal of Pharmacology publishes biennial updates to its Concise Guide to Pharmacology.
• The guide offers a comparative overview of drug target families, summarizing key pharmacological properties.

Purpose of the Study:

• To provide a stable, citable, point-in-time record of human drug targets and their interactions.
• To offer expert-curated recommendations of selective pharmacological tools for target identification.
• To present official International Union of Basic and Clinical Pharmacology (NC-IUPHAR) classification and nomenclature for drug targets.

Main Methods:

• Summarizing pharmacological properties of approximately 1900 human drug targets and nearly 7000 interactions.
• Condensing detailed information from the www.guidetopharmacology.org website into a 500-page printed guide.
• Dividing content into six major pharmacological target families: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes, and transporters.

Main Results:

• The 2025/26 edition summarizes around 1900 human drug targets and nearly 7000 interactions.
• It includes nomenclature guidance, concise summaries, information on pharmacological tools, key references, and further reading suggestions.
• The guide serves as a permanent record, distinct from the continuously updated online database.

Conclusions:

• The Concise Guide to Pharmacology 2025/26 is a valuable resource for researchers, providing a structured overview of drug targets and pharmacological tools.
• It acts as a permanent, citable reference, complementing the comprehensive online database.
• The publication ensures standardized nomenclature and recommendations for pharmacological research.