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Rapid virus-free production of recombinant yellow fever virus envelope protein and its in-depth biophysical analysis

Luca Schelle1, Wolfgang Kuttenlochner1, Victoria Sanchez2

  • 1Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research IIP, Nonnenwald 2, D-82377, Penzberg, Germany.

Scientific Reports
|December 30, 2025
PubMed
Abstract

No abstract available in PubMed .

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Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...