H₂S Signaling and SKM Physiopathology

Area of Science:

• Biochemistry
• Physiology
• Molecular Biology

Background:

• Hydrogen sulfide (H₂S) is an endogenous gasotransmitter with recognized physiological roles.
• Historically viewed as toxic, H₂S now shows cytoprotective effects like antioxidant and anti-inflammatory actions.
• Skeletal muscle disorders (e.g., sarcopenia, muscular dystrophy) cause significant functional impairment.

Purpose of the Study:

• To explore the dual role of hydrogen sulfide (H₂S) in skeletal muscle (SKM) physiology and pathophysiology.
• To highlight the potential therapeutic applications of H₂S in SKM health.
• To review emerging evidence on H₂S's protective effects against muscle damage.

Main Methods:

• Literature review of existing studies on H₂S and skeletal muscle.
• Analysis of H₂S's antioxidant, anti-inflammatory, and antifibrotic properties.
• Exploration of H₂S's involvement in SKM disorders.

Main Results:

• H₂S exhibits cytoprotective properties relevant to skeletal muscle health.
• Emerging evidence suggests H₂S can mitigate muscle damage and dysfunction.
• Limited but growing literature indicates H₂S's role in SKM physiopathology.

Conclusions:

• H₂S plays a dual role in skeletal muscle, with potential protective functions.
• H₂S-based strategies may offer therapeutic benefits for muscle-related disorders.
• Further investigation is warranted to understand H₂S mechanisms in SKM.