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Updated: Jan 7, 2026

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
Published on: January 13, 2019
Impact of spaceflight on endocrine, metabolic and kidney function: current evidence, open issues, and potential
Paolo Magni1,2, Giulia Ricci3, Marco Narici4
1Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Università Degli Studi Di Milano, Milan, Italy. paolo.magni@unimi.it.
Abstract:
Changes in endocrine and kidney functions have been associated with spaceflight. Here, we discuss the most relevant evidence about the impact of spaceflight on the cardiometabolic system, the cardiorenal function and the reproductive/gonadal axis. Notably, these changes appear to be interrelated with other organ/system functions, suggesting the need of a systemic approach leading to a more comprehensive understanding of physiological and health-related impacts of the space environment. Therefore, this review will also focus on the need to move space endocrinological research to multi-omics approaches and the implementation of "machine learning" and "data mining" strategies.
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