Prenatal exposure to hyperglycemia and child growth trajectories in the first 3 years of life: a prospective birth cohort
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View abstract on PubMed
Summary
This summary is machine-generated.Infants exposed to hyperglycemia in pregnancy (HIP) experienced slower early childhood growth. HIP-exposed children were more likely to follow a high-decreasing weight-for-length trajectory, indicating potential long-term growth regulation issues.
Area Of Science
- Pediatric Endocrinology
- Developmental Pediatrics
- Maternal-Fetal Medicine
Background
- Infants exposed to hyperglycemia in pregnancy (HIP) face risks like macrosomia and adult obesity.
- Longitudinal growth patterns in early childhood for HIP-exposed infants are not well understood.
- This study investigates HIP's impact on early childhood growth trajectories.
Purpose Of The Study
- To examine differences in early childhood growth trajectories associated with maternal HIP.
- To identify specific growth patterns in infants exposed to HIP in utero.
- To understand the long-term implications of HIP on child growth regulation.
Main Methods
- Utilized data from the Jiangsu Birth Cohort (JBC) study, including 8780 children.
- Employed linear mixed models to analyze associations between maternal HIP and child growth measures (0-36 months).
- Applied latent class mixed models (LCMM) to identify weight-for-age, length/height-for-age, and weight-for-length z-score trajectories.
Main Results
- Maternal HIP was linked to lower weight-for-age, length/height-for-age, and weight-for-length z-scores in children up to 36 months.
- HIP exposure correlated with reduced growth velocity in weight and BMI during specific early periods (0-3 and 6-8 months).
- HIP-exposed children showed a higher likelihood (aRR=1.14) of following a high-decreasing weight-for-length trajectory.
Conclusions
- Maternal HIP is associated with slower early childhood growth.
- HIP exposure increases the probability of a high-decreasing growth trajectory in infants.
- These findings suggest potential long-term effects of HIP on a child's growth regulation.
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