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Published on: February 23, 2024
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Spontaneous Second Molar Migration After MIH-Affected First Molars Extraction: A Radiographic-Based Method
Santo Andrea Stabilini1,2, Lucia Giannini1,2, Niccolò Cenzato1,2
1Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.
Children (Basel, Switzerland)
|December 30, 2025
Summary
Early extraction of first permanent molars (FPM) in severe molar-incisor hypomineralization (MIH) cases effectively promotes spontaneous second permanent molar (SPM) mesialization, especially in the maxilla. Novel radiographic methods reliably assess this movement and associated factors.
Area of Science:
- Dentistry
- Orthodontics
- Radiology
Background:
- Molar-incisor hypomineralization (MIH) presents significant dental challenges, often necessitating first permanent molar (FPM) extraction in severe cases.
- Assessing spontaneous second permanent molar (SPM) mesialization post-FPM extraction and identifying influencing factors remain underexplored areas.
Purpose of the Study:
- To evaluate novel radiographic methods for assessing spontaneous SPM mesialization after FPM extraction.
- To identify clinical and developmental factors correlated with complete space closure following FPM extraction.
Main Methods:
- Analysis of Orthopantomograms (OPTs) from 19 patients undergoing FPM extraction due to MIH.
- Application of novel geometric measurements to quantify SPM movement pre- and post-extraction.
- Evaluation of factors including age, developmental stage (Demirjian index), observation period, and third permanent molar (TPM) presence.
Main Results:
- Complete or near-complete SPM mesialization observed in 78.6% of maxillary and 73.7% of mandibular sites.
- Maxillary SPMs demonstrated more favorable spontaneous movement, including significant uprighting and higher rates of space closure.
- SPM developmental stages D-E were associated with successful mesialization outcomes.
Conclusions:
- Early FPM extraction is an effective strategy for promoting SPM mesialization, particularly in the maxilla.
- The developed radiograph-based measurement method offers high reliability and reproducibility for clinical and research use.
- This novel approach provides a valuable tool for assessing treatment outcomes in MIH patients.

