Related Experiment Video
Updated: Jan 7, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
12.1K
Biological Plausibility Between Long-COVID and Periodontal Disease Development or Progression
Oelisoa Mireille Andriankaja1, Sidney Whiteheart2, Marcelo Barbosa de Accioly Mattos3
1Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY 40508, USA.
Biomedicines
|December 30, 2025
Summary
Long COVID (LC) may increase the risk of developing periodontitis due to shared immunoinflammatory pathways and potential oral microbiome changes. Further research is needed to confirm this link between long COVID and gum disease.
Area of Science:
- Oral Health Research
- Infectious Disease Immunology
- Systemic Health
Background:
- Long COVID (LC) presents as a multi-system disorder with persistent symptoms post-SARS-CoV-2 infection.
- The oral cavity's susceptibility to SARS-CoV-2 suggests a potential link to periodontal health.
- Understanding this connection is crucial for comprehensive patient care.
Purpose of the Study:
- To explore the potential impact of Long COVID on periodontal health.
- To review the existing literature on the interplay between LC and oral diseases.
- To identify future research directions in this emerging field.
Main Methods:
- A comprehensive literature search was performed in PubMed using keywords for LC and periodontal diseases.
- Articles were filtered for English-language, full-text publications from 2019-2024.
- The review incorporated studies on pathogenesis, immune mechanisms, microbiome alterations, and clinical outcomes.
Main Results:
- LC involves systemic immunoinflammatory dysregulation overlapping with periodontitis mechanisms.
- Alterations in gut and lung microbiomes during LC may affect oral microbial communities.
- ACE2 expression in gingival cells and viral reactivation link LC to periodontitis pathogenesis.
Conclusions:
- Long COVID may serve as a systemic risk factor for periodontitis.
- This review establishes a theoretical basis for LC's interaction with oral health.
- Further epidemiologic and mechanistic studies are essential to elucidate these relationships.
Related Concept Videos
01:20COPD: Pathogenesis and Clinical Features
1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K
01:29Biofilms
1.0K
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
1.0K
01:15Teeth
1.6K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
1.6K