Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive Genomic Profiling for Precision Oncology: Analytical Validation and Clinical Utility in Solid Tumors.

Diagnostics (Basel, Switzerland)·2026
Same author

Neuroinflammatory and functional outcomes after TBI are sex-dependent: Lessons from estrous-phase stratified female mice.

Neurochemistry international·2026
Same author

Understanding Non-Small-Cell Lung Cancer: Biology, Therapeutics and Drug Resistance.

Biomedicines·2026
Same author

Extracellular vesicle-derived miRNA-182-5p educates macrophages towards an immunosuppressive phenotype in pancreatic cancer.

Signal transduction and targeted therapy·2026
Same author

PARP inhibition generates enhanced CD8<sup>+</sup> central memory T cells by transcriptional and metabolic reprogramming.

Nature immunology·2026
Same author

TIMP-1 Modulation Correlates with KRAS Dependency and EMT Induction in NSCLC.

Cells·2025

Related Experiment Video

Updated: Jan 7, 2026

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.6K

Brain Injury and Neurodegeneration: Molecular, Functional, and Translational Approach 3.0.

Pankaj Gaur1, Meenakshi Ahluwalia2,3, Pankaj Ahluwalia2

  • 1Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

Biomedicines
|December 30, 2025
PubMed
Summary

Brain injuries and diseases involve complex, multifaceted pathologies beyond neuroinflammation. These conditions encompass ischemic injury, glial activation, metabolic issues, and extracellular vesicle signaling, contributing to neurodegeneration and other systemic illnesses.

Area of Science:

  • Neuroscience
  • Pathology
  • Biomedical Research

Background:

  • Brain injury and disease are complex, extending beyond traditional neuroinflammation and neuronal loss.
  • Recent understanding highlights a multifaceted pathology involving intricate mechanistic pathways.

More Related Videos

Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging
11:14

Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging

Published on: April 6, 2014

12.9K
An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices
07:57

An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices

Published on: April 11, 2018

7.3K

Related Experiment Videos

Last Updated: Jan 7, 2026

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.6K
Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging
11:14

Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging

Published on: April 6, 2014

12.9K
An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices
07:57

An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices

Published on: April 11, 2018

7.3K