High-Dose Transarterial Radioembolization of Hepatic Metastases Using Yttrium-90 Resin Microspheres

Area of Science:

• Interventional Radiology
• Nuclear Medicine
• Oncology

Background:

• High-dose radioembolization (≥150 Gy) is established for primary liver cancer but less studied for hepatic metastases.
• Transarterial radioembolization (TARE) with Yttrium-90 (⁹⁰Y) resin microspheres is a targeted therapy.

Purpose of the Study:

• To evaluate the safety and efficacy of high-dose TARE in patients with hepatic metastases.
• To assess treatment response, toxicity, and survival outcomes.

Main Methods:

• Retrospective analysis of 15 patients with hepatic metastases treated with high-dose ⁹⁰Y resin microsphere TARE.
• Efficacy assessed by radiological response (RECIST 1.1), time to progression, and overall survival (OS).
• Toxicity graded per NCI CTCAE v5.0; dosimetry analyzed using ⁹⁰Y PET/CT.

Main Results:

• All 15 patients achieved disease control (10 partial response, 5 stable disease) at 3 months.
• Median overall survival was 26.5 months.
• Favorable safety profile with only grade 3 laboratory toxicity in 2 patients; no grade 4/5 toxicities observed.

Conclusions:

• High-dose TARE with ⁹⁰Y resin microspheres is safe and effective for hepatic metastases.
• Achieves high disease control rates even in heavily pretreated patients.
• Offers a promising therapeutic option with a favorable safety profile.