Examination of Appendiceal Neoplasms-A Retrospective, Single-Centre, Cohort Study

Area of Science:

• Gastroenterology
• Pathology
• Oncology

Background:

• Appendiceal neoplasms are rare but show a rising incidence, particularly in younger individuals.
• Diagnosis is often incidental during histopathological examination of appendectomy specimens.
• This study focuses on the incidence and histological subtypes in Southern Hungary.

Purpose of the Study:

• To determine the incidence and histological spectrum of appendiceal neoplasms.
• To analyze the characteristics and associations of these tumors in a specific population.
• To compare findings with international trends and emphasize clinical implications.

Main Methods:

• Retrospective analysis of neoplastic appendix specimens from the University of Szeged (2014-2023).
• Inclusion of 3640 appendectomy cases, identifying 71 with neoplasms.
• Histopathological classification and statistical analysis of tumor subtypes and associated conditions.

Main Results:

• Appendiceal neoplasms were found in 1.9% of cases (71/3640).
• Benign lesions (37%) were most commonly sessile serrated lesions; mucinous and malignant neoplasms (63%) were most frequently low-grade appendiceal mucinous neoplasm and neuroendocrine tumors.
• Associated colorectal neoplasms were found in 50% of benign and 42.2% of malignant cases, with significant correlations between tumor characteristics and associated colorectal carcinoma.

Conclusions:

• The appendiceal neoplasm prevalence aligns with international data, but an upward trend is suggested by raw numbers.
• The high incidence of associated colorectal neoplasms necessitates thorough pathological evaluation and long-term surveillance.
• Findings emphasize the importance of recognizing appendiceal neoplasms and their potential links to colorectal malignancies.