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Silent Players, Loud Impact: The Influence of lncRNAs on Melanoma Progression

Kajetan Kiełbowski1, Maciej Ćmil1, Aleksandra Dach1

  • 1Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.

Cancers
|December 30, 2025
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key gene regulators implicated in cancer. This review details lncRNA roles in melanoma pathophysiology, highlighting potential biomarkers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Non-coding RNAs (ncRNAs) regulate gene expression and are vital in physiological and pathological processes.
  • ncRNAs, including microRNAs and long non-coding RNAs (lncRNAs), play significant roles in oncogenesis.
  • lncRNAs are increasingly recognized for their involvement in cancer development and progression.

Purpose of the Study:

  • To comprehensively review the latest findings on the roles of lncRNAs in melanoma pathophysiology.
  • To discuss key aspects of melanoma biology influenced by lncRNAs.
  • To present future directions for lncRNA-based biomarkers and therapeutics in melanoma.

Main Methods:

  • Literature review of recent studies on lncRNAs and melanoma.
  • Analysis of lncRNA mechanisms in melanoma development and progression.
  • Synthesis of current knowledge on lncRNA functions in melanoma.

Main Results:

  • lncRNAs are implicated in regulating tumor suppressors and oncogenes in melanoma.
  • Specific lncRNAs are identified as crucial mediators in melanoma pathophysiology.
  • lncRNAs contribute to various mechanisms driving melanoma progression.

Conclusions:

  • lncRNAs are critical players in the pathophysiology of melanoma.
  • Understanding lncRNA functions offers insights into melanoma biology.
  • lncRNAs represent promising targets for melanoma biomarkers and therapies.
Keywords:
long non-coding RNAmelanomaoncologypost-transcriptional regulationtranscription

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