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Implementation of a Stress Biomarker and Development of a Deep Neural Network-Based Multi-Mental State Classification

Sangsik Lee1, Jaehyun Jo1, Sohyeon Bang2

  • 1Department of Digital Healthcare, Catholic Kwandong University, 24 Beomil-ro 579 Beongil, Gangneung-si 25601, Republic of Korea.

Bioengineering (Basel, Switzerland)
|December 30, 2025
PubMed
Summary

A Transformer deep learning model accurately predicted stress levels using biosignal data, achieving 98% accuracy. This demonstrates the feasibility of large-scale, wearable stress monitoring systems.

Keywords:
biomarkermental health multi-classificationphysiological signalsstress predictiontransformer model

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Area of Science:

  • Biomedical Engineering
  • Data Science
  • Wearable Technology

Background:

  • Stress monitoring is crucial for public health.
  • Existing methods often rely on indirect measures or limited datasets.
  • Wearable biosensors offer potential for continuous, real-world stress assessment.

Purpose of the Study:

  • To develop and evaluate a deep learning model for predicting stress levels from large-scale biosignal data.
  • To assess the model's ability to interpret physiological patterns associated with stress.
  • To determine if a Transformer model can accurately reproduce stress indices derived from wearable devices.

Main Methods:

  • Utilized ~137,000 longitudinal biosignal measurements from Sejong City residents.
  • Integrated static machine learning (Random Forest, LightGBM) and deep learning (LSTM, Transformer) models.
  • Employed SHapley Additive exPlanations (SHAP) and Transformer attention visualization for interpretability.

Main Results:

  • The Transformer model achieved ~98% classification accuracy on the large dataset.
  • The model successfully captured both short-term biosignal fluctuations and long-term temporal structures.
  • Model interpretability methods quantified biomarker contributions and revealed temporal interactions.

Conclusions:

  • Deep learning models, particularly Transformers, can effectively predict stress levels from wearable biosignal data.
  • The study provides a methodological foundation for large-scale, wearable-based stress monitoring.
  • Engineering feasibility for a comprehensive stress monitoring system using device-derived data is demonstrated.