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The Prognostic Implications of the Geriatric Nutritional Risk Index in Patients with Prostate Cancer: A Single-Center

Rong Zhou1,2, Yanqiong Zhou1,2, Xiao Yue1,2

  • 1Department of Geriatrics Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China.

Healthcare (Basel, Switzerland)
|December 30, 2025
PubMed
Summary

Nutritional risk, identified by the Geriatric Nutritional Risk Index (GNRI), significantly increases postoperative complications and healthcare costs in older prostate cancer patients undergoing surgery.

Keywords:
agedhospital costslength of staynutritional statuspostoperative complicationsprostate cancer

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Area of Science:

  • Geriatric medicine
  • Oncology
  • Nutritional science

Background:

  • Nutritional status is a critical, often underestimated, factor affecting surgical outcomes in elderly prostate cancer patients.
  • The Geriatric Nutritional Risk Index (GNRI) is a tool for assessing nutritional risk.

Purpose of the Study:

  • To investigate the impact of GNRI-defined nutritional risk on postoperative complications in older men undergoing radical prostatectomy.
  • To examine the association between GNRI and healthcare resource utilization, including hospital stay duration and costs.

Main Methods:

  • Retrospective cohort study of 264 patients aged 65+ undergoing laparoscopic radical prostatectomy.
  • Patients were categorized by GNRI score (≤98: malnutrition; >98: normal nutrition).
  • Statistical analyses included chi-square, t-tests, and logistic regression to identify predictors of outcomes.

Main Results:

  • 34.8% of patients were identified as being at nutritional risk.
  • The malnutrition group exhibited significantly higher rates of postoperative complications (OR=2.859), longer hospital stays (OR=4.678), and increased costs (OR=4.867).
  • Nutritional risk was an independent predictor of adverse outcomes even after adjusting for confounding factors.

Conclusions:

  • GNRI-defined nutritional risk is independently linked to increased postoperative complications and healthcare resource utilization in elderly prostate cancer patients.
  • The GNRI serves as a valuable and readily available tool for perioperative risk assessment in this demographic.