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Curcumin Modulates TIGIT/Neuropilin-1 to Regulate T-Cell Immune Homeostasis in Ulcerative Colitis.

Yazhen Liu1,2, Jiaqi Huang1,2, Ji Yu1,2

  • 1Graduate School, Jiangxi University of Chinese Medicine, Nanchang 330004, China.

Foods (Basel, Switzerland)
|December 30, 2025
PubMed
Summary

Curcumin (CUR) helps ulcerative colitis (UC) by restoring T cell balance. It works by downregulating TIGIT and Neuropilin-1 (NRP1) to reduce T cell activation and improve gut inflammation.

Keywords:
CD4+ T cellsNeuropilin-1TIGITcurcuminmemory T cellsulcerative colitis

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