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Related Concept Videos

MicroRNAs01:22

MicroRNAs

3.7K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.7K
MicroRNAs01:22

MicroRNAs

23.8K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.8K

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Related Experiment Video

Updated: Jan 7, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
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miRNA as a Prognostic Marker in Small Lung Cell Carcinoma.

Michał Bednarz1, Aleksandra Osińska1, Julia Durda1

  • 1Student Scientific Society of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland.

Genes
|December 30, 2025
PubMed
Summary

MicroRNAs (miRNAs) are key regulators in aggressive small-cell lung carcinoma (SCLC). Profiling these molecules offers potential for non-invasive monitoring and improved precision oncology treatments for SCLC patients.

Keywords:
Hippo pathwayPI3K/AktSCLCbiomarkerchemoresistanceexosomesmiRNAmicroRNAprognosissmall-cell lung carcinoma

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Small-cell lung carcinoma (SCLC) is a highly aggressive malignancy with limited effective biomarkers.
  • Current treatments for SCLC face challenges due to rapid progression, metastasis, and relapse.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in regulating SCLC biology.
  • To discuss the potential clinical applications of miRNAs as biomarkers and therapeutic targets in SCLC.

Main Methods:

  • A narrative literature review was conducted.
  • Searches of PubMed and Scopus databases were performed to identify relevant studies on miRNAs in SCLC.

Main Results:

  • Fourteen specific miRNAs (e.g., miR-7-5p, miR-22-3p) were identified as regulators of SCLC progression, metastasis, and therapy resistance.
  • These miRNAs influence key signaling pathways like PI3K/Akt, Hippo, and DNA repair.
  • Abnormal miRNA expression correlates with patient outcomes and suggests potential for non-invasive monitoring via plasma or exosomes.

Conclusions:

  • MicroRNAs are central to SCLC pathogenesis and progression.
  • miRNA profiling holds promise for refining SCLC diagnosis, risk assessment, and therapeutic strategies.
  • miRNA-based therapeutics (mimics, antagomiRs) may enhance drug sensitivity and complement existing SCLC treatments.