Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

17.4K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
17.4K
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

1.1K
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BAP1 and PBRM1 Loss Is Associated with Aggressive Clinicopathological Features in Clear Cell Renal Cell Carcinoma: Prognostic Implications in a 10-Year Surgical Cohort.

Diagnostics (Basel, Switzerland)·2026
Same author

Prioritising Data Quality Governance for AI in Prostate Cancer: A Methodological Proof-of-Concept Study Using Neural Networks for Risk Stratification.

Diagnostics (Basel, Switzerland)·2026
Same author

Health-Related Quality of Life Among Food Bank Users in Spain: A Cross-Sectional Study.

Healthcare (Basel, Switzerland)·2026
Same author

Diagnostic Role and Clinical Impact of Zr-Girentuximab PET-CT for the Diagnosis and Treatment of Clear-Cell Renal Cell Carcinoma.

Diagnostics (Basel, Switzerland)·2026
Same author

Explainable machine learning algorithms for predicting maternal obstetric complications in Ethiopia: Evidence from a retrospective cohort in southern Ethiopia.

Health informatics journal·2026
Same author

Diagnostic Accuracy of PSMA-PET/CT vs. mpMRI in Primary Staging of Intermediate- and High-Risk Prostate Cancer.

Medical sciences (Basel, Switzerland)·2026
Same journal

Correction: Yalçın et al. Impact of SGLT2 Inhibitors on Cardiovascular Risk Scores, Metabolic Parameters, and Laboratory Profiles in Type 2 Diabetes. <i>Life</i> 2025, <i>15</i>, 722.

Life (Basel, Switzerland)·2026
Same journal

Correction: Schubert et al. Minimally Invasive Ablation Strategies for Renal Cell Carcinoma Patients Ineligible for Surgery. <i>Life</i> 2026, <i>16</i>, 73.

Life (Basel, Switzerland)·2026
Same journal

Blood Group Antigen Combinations and COVID-19: Complexity, Associations and Possible Clinical Relevance.

Life (Basel, Switzerland)·2026
Same journal

Beyond HPV in Eastern Europe: Genotype Distribution, Molecular Biomarkers, Vaginal Microbiome, and Implications for Cervical Cancer Prevention.

Life (Basel, Switzerland)·2026
Same journal

Therapeutic Effects of <i>Scutellaria baicalensis</i> Georgi Extract and Baicalein on Olfactory Dysfunction and Neurobehavioral Alterations in a Methimazole-Induced Injury Model.

Life (Basel, Switzerland)·2026
Same journal

The Effects of Unstable Strength Training on Lower Limb Stability in Adolescent Volleyball Players in China.

Life (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
08:03

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Published on: June 6, 2018

15.0K

Intracavernosal Botulinum Toxin Injection for Erectile Dysfunction: A Comprehensive Systematic Review.

Vanessa Talavera Cobo1, Carlos Andres Yanez Ruiz1, Mario Daniel Tapia Tapia1

  • 1Department of Urology, Clinica Universidad de Navarra, Av. Pío XII 36, 31008 Pamplona, Spain.

Life (Basel, Switzerland)
|December 30, 2025
PubMed
Summary
This summary is machine-generated.

Intracavernosal onabotulinumtoxinA (BoNT-A) shows promise for treating erectile dysfunction (ED) in non-responders to standard therapies. This novel treatment may improve sexual function with a favorable safety profile, offering an alternative to invasive options.

Keywords:
PDE5 inhibitorsbotulinum toxin type Aerectile dysfunctionintracavernosal injectionrefractorysystematic review

More Related Videos

Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation
03:51

Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation

Published on: December 8, 2023

4.3K
Intracavernous Pressure Recording in a Cavernous Nerve Injury Rat Model
05:48

Intracavernous Pressure Recording in a Cavernous Nerve Injury Rat Model

Published on: September 20, 2021

1.9K

Related Experiment Videos

Last Updated: Jan 7, 2026

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
08:03

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Published on: June 6, 2018

15.0K
Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation
03:51

Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation

Published on: December 8, 2023

4.3K
Intracavernous Pressure Recording in a Cavernous Nerve Injury Rat Model
05:48

Intracavernous Pressure Recording in a Cavernous Nerve Injury Rat Model

Published on: September 20, 2021

1.9K

Area of Science:

  • Urology
  • Pharmacology
  • Regenerative Medicine

Background:

  • Erectile dysfunction (ED) affects 20% of men globally, impacting quality of life.
  • Phosphodiesterase type 5 inhibitors (PDE5-Is) are first-line treatments, but many patients are non-responders.
  • Intracavernosal alprostadil is effective but invasive; intracavernosal onabotulinumtoxinA (BoNT-A) presents a novel alternative.

Purpose of the Study:

  • To systematically review the efficacy and safety of intracavernosal onabotulinumtoxinA (BoNT-A) for treating erectile dysfunction (ED).
  • To evaluate BoNT-A as a potential therapeutic option for patients with refractory ED.
  • To assess the potential of BoNT-A to reduce treatment burden and improve adherence.

Main Methods:

  • A systematic review adhering to PRISMA guidelines was conducted.
  • Searches were performed across major databases (PubMed, Embase, Cochrane, Scopus, Clinicaltrials.gov) using relevant keywords and MeSH terms.
  • 51 studies were included, with data synthesized via narrative synthesis due to heterogeneity.

Main Results:

  • Intracavernosal BoNT-A demonstrated improvements in erectile function scores across studies.
  • Reported response rates varied from 40% to 77.5%.
  • The treatment showed a favorable safety profile, with mild penile pain as the most common adverse event; no serious systemic events were reported.

Conclusions:

  • Intracavernosal onabotulinumtoxinA (BoNT-A) may be a beneficial option for refractory ED patients.
  • BoNT-A offers potential improvements in sexual function and reduces reliance on invasive therapies.
  • Further large-scale, placebo-controlled trials are needed to confirm efficacy and standardize clinical use.