Related Experiment Video
Updated: Jan 7, 2026
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Low-grade oncocytic tumor of kidney: A case report
Ting-Shuo Kang1, Yi-Zhong Chen
1Division of Urology, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan.
Rationale:
Low-grade oncocytic tumor (LOT) is characterized by cells with oncocytic/eosinophilic cytoplasm. Despite the clear definition of the tumor, challenges persist as some tumors resemble LOT, complicating the diagnosis. Therefore, understanding its characteristics is crucial for accurate diagnosis and differentiation from other renal oncocytic tumors.
Patient Concerns:
An 81-year-old woman was incidentally found to have a right renal mass during routine examination.
Diagnoses:
Histological examination of the specimen obtained from a partial nephrectomy revealed oncocytic cells with abundant eosinophilic granular cytoplasm, indistinct cell borders, uniform round nuclei, and inconspicuous nucleoli, arranged in small nesting and trabecular patterns. A vague peri-nuclear halo was also observed. Immunohistochemistry demonstrated significant positivity for CK7, while CD117, CA9, GATA3, CK20, RCC, and GPNMB were negative. Based on these findings, we diagnosed the tumor as a LOT.
Interventions:
The patient underwent partial nephrectomy for tumor removal.
Outcomes:
There was no evidence of recurrence or metastasis during follow-up.
Lessons:
LOT can exhibit variations in its immunohistochemical profile. Therefore, additional studies and the accumulation of similar cases are necessary.
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
01:20Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
01:25Chronic Kidney Disease I: Introduction
01:21External Anatomy of the Kidney
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
01:28Imaging Studies I: Kidney, Ureter, and Bladder Studies
01:45Kidney Structure