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Related Concept Videos

Properties of Organometallic Compounds01:23

Properties of Organometallic Compounds

1.6K
Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.
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Structural Isomerism02:34

Structural Isomerism

21.4K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
21.4K
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

23.8K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
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Coordination Number and Geometry02:57

Coordination Number and Geometry

18.7K
For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
18.7K
Conformations of Cyclohexane02:11

Conformations of Cyclohexane

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Cyclohexane does not exist in a planar form due to the high angle and torsional strain it would experience in the planar structure. Instead, it adopts non-planar chair and boat conformations.
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...
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Stereoisomerism02:52

Stereoisomerism

13.8K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
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Homochiral Metal-Organic Framework Featuring Transformable Helical and Sheeted Structures.

Xiang-Shuai Li1, Peiqi Zhang1, Fang-Yu Ren2

  • 1Department of Chemistry, The Hong Kong University of Science and Technology, Kowloon, Hong Kong 999077, China.

Journal of the American Chemical Society
|December 30, 2025
PubMed
Summary
This summary is machine-generated.

Researchers synthesized novel homochiral metal-organic frameworks (MOFs) with tunable rigidity and flexibility. These adaptable MOFs can host dyes, inducing chiroptical properties, advancing chiral material design.

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Area of Science:

  • Biochemistry
  • Materials Science
  • Supramolecular Chemistry

Background:

  • Artificial protein mimics are crucial for understanding chirality transfer in complex 3D structures.
  • Synthesizing protein-like crystalline materials is challenging due to the need to balance rigidity and flexibility.
  • Existing artificial materials with defined structures are limited.

Purpose of the Study:

  • To synthesize homochiral metal-organic frameworks (MOFs) with controllable structural rigidity and flexibility.
  • To investigate the chirality transfer from amino acids to 3D MOF architectures.
  • To explore the potential of these MOFs as hosts for inducing chiroptical activities.

Main Methods:

  • Synthesis of cysteine-derived homochiral MOFs (L/D-Zn-PDT-α and L/D-Zn-PDT-β) using linkers with rigid and flexible motifs.
  • In situ monitoring of crystal transformations between different MOF phases.
  • Systematic crystallographic analyses to determine coordination modes and structural properties.

Main Results:

  • Successfully synthesized L/D-Zn-PDT-α (helical) and L/D-Zn-PDT-β (pleated-sheet) MOFs.
  • Observed an in situ transformation from a rigid Zn-PDT-α phase to a more flexible Zn-PDT-β phase.
  • Demonstrated that coordination mode dictates the rigidity/flexibility of the MOF structure.
  • Showcased L/D-Zn-PDT-β's ability to host achiral dyes, inducing chiroptical activity.

Conclusions:

  • Developed homochiral MOFs with tunable structural properties by controlling linker motifs and coordination modes.
  • Established a pathway for designing adaptable chiral materials with potential applications in chiroptical sensing and functional materials.
  • The study provides insights into chirality transfer and the design of complex chiral assemblies.