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Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
Published on: June 13, 2020
Probiotics and quality of life improvement in cancer therapy
Himani Muniyal Jheetay1, Nikhil Menia2, Kishore Chandra Thakur3
1Department of Biochemistry, GEIMS, Dehradun, Uttrakhand, India.
Abstract:
Gastrointestinal toxicity and mental fatigue are common with cancer therapy by reducing patient quality of life. In this observational study patients taking Lactobacillus probiotic had better role function (6.52 vs 6.20, p=0.016), emotional balance (11.96 vs 11.58, p=0.020) and cognitive clarity (6.42 vs 6.20, p=0.037) after 6 weeks. Diarrhoea severity was lower (0.78 vs 1.26, p<0.001) and fewer needed rescue loperamide (24% vs 44%, p=0.034). Thus, we show probiotics help patients adapt better to treatment stress and protect gut-brain axis during chemotherapy and radiotherapy.
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