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Updated: Jan 7, 2026

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
Published on: December 10, 2021
Prospective cohort study on the relationship between long-term air pollution exposure and risk of myocardial
Rahil Abdusamad Nainam Valappil1, Anjaly Mecheril Chandran2, Shameela Farha3
1Department of Critical Care, Iqraa International Hospital, Calicut, Kerala, India.
Abstract:
The relationship between long-term air pollution exposure and risk of myocardial infarction is of interest. Hence, this five-year prospective cohort study examined 132 adults between the ages of 40 and 65 to determine whether long-term exposure to air pollutants (PM2.5, NO2, and SO2) was associated with an increased risk of myocardial infarction (MI). Participants who lived in metropolitan regions with high pollution levels had a noticeably higher incidence of MI than those who lived in locations with low exposure levels. According to adjusted risk models, PM2.5 is the most reliable independent predictor of MI incidence. High-exposure individuals also showed significantly higher levels of biomarkers of systemic inflammation. In order to reduce cardiovascular risks, the highlight the necessity of strict air quality restrictions.
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