Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 7, 2026

In Ovo and Ex Ovo Methods to Study Avian Inner Ear Development
10:09

In Ovo and Ex Ovo Methods to Study Avian Inner Ear Development

Published on: June 16, 2022

2.8K

Inner ear organoids: Recent progress and potential applications.

Yiyun Lou1,2, Yaoqian Liu1,2, Mingxuan Wu1,2

  • 1ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.

Fundamental Research
|December 30, 2025
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interferon-elicited lipoprotein metabolism in lung fibroblasts facilitates premetastatic niche formation.

Nature communications·2026
Same author

Immunopharmacology of GPR35: Context-driven signaling and functional plasticity in host defense.

Biochemical pharmacology·2026
Same author

Burden and causes of hearing loss among different genders and ages in China: a secondary analysis of the 2019 global burden of disease study.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same author

Versatile Sulfonium Tools for Chemoselective Modification of Proteins.

Biochemistry·2026
Same author

A Methyltransferase Catalyzing Reactions More Than Methylation.

Journal of the American Chemical Society·2026
Same author

Unlocking circular potential in under-prioritized industries: Plant-by-plant industrial symbiosis plan in the light and stone processing industries.

Journal of environmental management·2026

Inner ear organoids offer a promising model for studying hearing and balance disorders. This review details their development, applications in modeling diseases like hereditary deafness, and strategies for hair cell regeneration.

Area of Science:

  • Otolaryngology
  • Regenerative Medicine
  • Developmental Biology

Background:

  • The inner ear, crucial for hearing and balance, is anatomically complex and difficult to study.
  • Organoids provide a valuable model for investigating inner ear development and diseases.
  • Inner ear organoid research is advancing therapeutic strategies for auditory and vestibular disorders.

Purpose of the Study:

  • To review the historical development and progress of inner ear organoid research.
  • To summarize cell sources and matrix components used in organoid formation.
  • To explore the applications of inner ear organoids in understanding development, disease modeling, and regenerative therapies.

Main Methods:

  • Review of existing literature on inner ear organoid research.
Keywords:
3D cultureHair cellInner earOrganoidStem cell

More Related Videos

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
12:17

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells

Published on: January 2, 2016

8.9K
In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti
08:08

In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti

Published on: December 4, 2020

4.2K

Related Experiment Videos

Last Updated: Jan 7, 2026

In Ovo and Ex Ovo Methods to Study Avian Inner Ear Development
10:09

In Ovo and Ex Ovo Methods to Study Avian Inner Ear Development

Published on: June 16, 2022

2.8K
Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
12:17

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells

Published on: January 2, 2016

8.9K
In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti
08:08

In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti

Published on: December 4, 2020

4.2K
  • Summarization of cell sources, including pluripotent stem cells (PSCs) and primary progenitor cells.
  • Analysis of organoid applications in developmental studies, hereditary deafness modeling, and hair cell regeneration.

    • Main Results:

    • Detailed history of inner ear organoids derived from PSCs and primary cells.
    • Elaboration on organoid applications for inner ear development and hereditary deafness modeling.
    • Identification of strategies for hair cell (HC) regeneration using organoid models.

    Conclusions:

    • Inner ear organoids are vital tools for advancing our understanding of inner ear biology and pathology.
    • Current limitations in culture methods and applications necessitate further optimization for translational use.
    • Future prospects focus on developing next-generation organoids for enhanced therapeutic applications in inner ear disorders.