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Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Prognostic Determinants and Treatment Strategies Associated with Long-Term Survival in Early-Stage Hepatocellular

Kuan Chen Pan1, Hui-Ling Huang1,2, Sheng-Nan Lu1,2,3

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.

Journal of Hepatocellular Carcinoma
|December 30, 2025
PubMed
Summary

Long-term survival in early-stage hepatocellular carcinoma (HCC) depends on age, liver function, and treatment. Curative treatments significantly improve outcomes and tumor-free status, especially for patients with HBV-related HCC.

Keywords:
early-stage HCClong-term survivalprognostic factorstreatment strategy

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Area of Science:

  • Hepatology
  • Oncology
  • Cancer Research

Background:

  • Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality globally, with high prevalence in Taiwan.
  • Early-stage HCC offers favorable outcomes with curative treatments, but long-term prognostic factors and strategies remain uncertain.

Purpose of the Study:

  • To identify prognostic factors influencing long-term survival in early-stage HCC.
  • To evaluate treatment outcomes and tumor-free status (TFS) in different long-term survival groups.

Main Methods:

  • Retrospective analysis of 1144 BCLC stage 0 or A HCC patients (2011-2020).
  • Cox regression for prognostic factor evaluation.
  • Subgroup analyses for patients surviving >5 years, stratified into 5-10 and >10 years survival groups.

Main Results:

  • Age >65, Child-Pugh B, and non-curative treatment were poor prognostic factors.
  • HBV-related HCC was associated with improved survival.
  • Patients surviving >10 years showed higher TFS rates and lower stage progression; curative treatment significantly increased TFS (p=0.044).

Conclusions:

  • Long-term survival in early-stage HCC is multifactorial, influenced by age, liver function, viral etiology, and treatment.
  • Curative treatments are crucial for improving outcomes and achieving TFS.
  • Maintaining curative options is vital for early-stage HCC patients experiencing recurrence.