Global burden and epidemiological trends of paediatric-onset multiple sclerosis: a cross-sectional analysis of the 2021 global burden of disease study
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View abstract on PubMed
Summary
This summary is machine-generated.Paediatric-onset Multiple Sclerosis (POMS) shows a low but increasing global disease burden. This study highlights the need for greater focus and new treatments for this rare autoimmune disorder in children and adolescents.
Area Of Science
- Neurology
- Epidemiology
- Autoimmune Diseases
Background
- Paediatric-onset Multiple Sclerosis (POMS) is a rare central nervous system autoimmune disorder affecting children and adolescents.
- Characterized by recurrent neurological impairment, POMS necessitates a comprehensive understanding of its global impact.
Purpose Of The Study
- To delineate the global disease burden and epidemiological characteristics of POMS.
- To analyze trends in POMS incidence, prevalence, and disability over three decades.
- To project the future disease burden of POMS using predictive modeling.
Main Methods
- Utilized data from the 2021 Global Burden of Disease (GBD) Study (1990-2021).
- Assessed global burden using incidence, prevalence, Disability-Adjusted Life Years (DALYs), and Years Lived with Disability (YLDs).
- Employed Joinpoint Regression for trend analysis and the Nordpred model for future projections.
Main Results
- In 2021, global POMS incidence was 1,899 and prevalence was 5,276.
- Global DALYs were 3,073 and YLDs were 1,489 in 2021.
- Trends from 1990-2021 showed increases in incidence and prevalence rates, while DALY rates decreased.
- Projections indicate a rise in ASIR and ASPR by 2046, with decreasing DALYs and YLDs rates.
Conclusions
- POMS exhibits a relatively low but persistently increasing disease burden.
- There is a critical need for increased research focus and the development of novel therapeutic strategies for POMS.
- Understanding epidemiological trends is crucial for managing and mitigating the impact of POMS in paediatric populations.
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