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Updated: Jan 7, 2026
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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
625
Risk of reclassification and novel tools in active surveillance
Bárbara Vieira Lima Aguiar Melão1,2, Lucas Mendes Nogueira3, Karim A Touijer4
1Division of Urology, University of São Paulo, São Paulo, Brazil.
Asian Journal of Urology
|December 30, 2025
Summary
Active surveillance for low-risk prostate cancer is effective but requires careful patient selection and monitoring. Novel tools show promise for improving risk stratification and reducing patient anxiety during follow-up.
Area of Science:
- Urology
- Oncology
- Medical Diagnostics
Background:
- Active surveillance (AS) is the preferred management for low-risk prostate cancer, aiming to reduce overtreatment.
- Effective AS relies on precise patient selection and robust monitoring to detect progression early.
- Early detection allows for timely treatment within the window of curability.
Purpose of the Study:
- To review novel diagnostic and prognostic tools for active surveillance in prostate cancer.
- To assess the role of these emerging tools in improving patient selection and monitoring.
- To evaluate strategies for decreasing reclassification rates and the need for frequent biopsies.
Main Methods:
- Comprehensive literature review of studies on prostate cancer reclassification.
- Evaluation of traditional and emerging diagnostic/prognostic tools.
- Inclusion of imaging modalities, biomarkers, and genomic classifiers.
Main Results:
- Long-term treatment rates in AS cohorts range from 30% to 45%.
- 36% of low-risk prostate cancer patients experience an upgrade in radical prostatectomy specimens.
- Few novel tools are validated for AS patient assessment, highlighting the need for better risk stratification.
Conclusions:
- Active surveillance is a feasible and safe strategy for low-risk prostate cancer.
- Novel risk stratification tools are promising but require further validation.
- Improved tools can enhance AS effectiveness and reduce patient monitoring burden and anxiety.
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