Jove
Visualize
Contact Us

Related Concept Videos

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

3.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.6K
Liver Regeneration01:24

Liver Regeneration

5.0K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of traction force during surgery on physical integrity and histological changes in peripheral nerves: experimental study on rabbits.

Cellular and molecular biology (Noisy-le-Grand, France)·2025
Same author

First study on molecular epidemiology of caseous lymphadenitis in slaughtered sheep and goats in Duhok Province, Iraq.

Open veterinary journal·2023
Same author

Age-related glomerular histogenesis in inbred indigenous rabbit (Oryctolagus cuniculus): A morphological, morphometrical, and immunohistochemical study with emphasis on Lgr5-positive cells.

Acta histochemica·2023
Same author

The effect of erythroferrone suppression by transfusion on the erythropoietin-erythroferrone-hepcidin axis in transfusion-dependent thalassaemia: A pre-post cohort study.

British journal of haematology·2022
Same author

Hepcidin-to-Ferritin Ratio as an Early Diagnostic Index of Iron Overload in β-Thalassemia Major Patients.

Hemoglobin·2022
Same author

Combination therapy with immune checkpoint inhibitors (ICIs); a new frontier.

Cancer cell international·2022
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 8, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

4.0K

Postnatal Hepatic Development and Lgr5+ve Cell Dynamics in Indigenous Rabbits: A Histomorphometric and

Ronak Saber Habib1, Burhan Abdullah Zaman2, Ramadhan Ado Khanamir3

  • 1Theriogenology, Anatomy, and Physiology Department, College of Vet. Medicine, University of Duhok, Duhok, Kurdistan Region, Iraq.

Anatomia, Histologia, Embryologia
|December 30, 2025
PubMed
Summary

Postnatal liver development in rabbits shows structural maturation and immune system remodeling by day 40. Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)+ve cells are key bipotential progenitors during this crucial growth period.

Keywords:
Lgr5+ve cellshistomorphometryimmunohistochemistryindigenous rabbitspostnatal liver development

More Related Videos

Pregnancy and Nursing Management for Embryo-Transferred and Genetically Modified Rabbits
04:29

Pregnancy and Nursing Management for Embryo-Transferred and Genetically Modified Rabbits

Published on: December 13, 2024

1.1K
X-ray Visualization of Intraductal Ethanol-based Ablative Infusion for Prevention of Breast Cancer in Rabbit Models
08:16

X-ray Visualization of Intraductal Ethanol-based Ablative Infusion for Prevention of Breast Cancer in Rabbit Models

Published on: September 12, 2025

785

Related Experiment Videos

Last Updated: Apr 8, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

4.0K
Pregnancy and Nursing Management for Embryo-Transferred and Genetically Modified Rabbits
04:29

Pregnancy and Nursing Management for Embryo-Transferred and Genetically Modified Rabbits

Published on: December 13, 2024

1.1K
X-ray Visualization of Intraductal Ethanol-based Ablative Infusion for Prevention of Breast Cancer in Rabbit Models
08:16

X-ray Visualization of Intraductal Ethanol-based Ablative Infusion for Prevention of Breast Cancer in Rabbit Models

Published on: September 12, 2025

785

Area of Science:

  • Hepatology and developmental biology.
  • Stem cell research and regenerative medicine.

Background:

  • The liver undergoes critical developmental changes in the early postnatal period.
  • Understanding these changes is vital for liver health and disease research.

Purpose of the Study:

  • To investigate postnatal liver development in rabbits (Oryctolagus cuniculus).
  • To analyze the role of leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)+ve cells in liver maturation.

Main Methods:

  • Histological and morphometric analyses of liver tissues from rabbits at different postnatal days (1, 10, 15, 30, 40).
  • Immunohistochemistry to detect Lgr5 expression and assess stem/progenitor cell activity.

Main Results:

  • Significant reduction in liver capsule thickness and maturation of hepatocytes and sinusoids observed.
  • Decreased hematopoietic activity and lipid droplets with age; organized liver architecture by day 30.
  • Peak Lgr5+ve cell activity at day 10, supporting hepatocyte and cholangiocyte development; Kupffer cells peaked at day 30.

Conclusions:

  • Postnatal liver development involves structural and immune remodeling, completed by day 40.
  • Transient Lgr5+ve cell activity is crucial for hepatic remodeling and biliary system development.
  • Findings offer insights into liver biology and potential regenerative therapies for liver and biliary diseases.