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Updated: Jan 7, 2026
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Association Between Elective Nodal Irradiation and Oncologic Outcomes in Node-Negative Olfactory Neuroblastoma and
Shuo-Fu Chen1, Yu-Wen Hu1,2, Chien-Fu Yeh2,3
1Department of Heavy Particles & Radiation Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.
Background:
The association between elective nodal irradiation (ENI) and oncological outcomes in clinically node-negative (cN0) sinonasal squamous cell carcinoma (SCC) and olfactory neuroblastoma (ONB) treated with postoperative chemoradiotherapy remains unclear.
Methods:
We retrospectively analyzed cN0 sinonasal SCC and ONB patients receiving postoperative chemoradiotherapy at a single institution. Propensity score matching was performed to minimize confounding. Survival outcomes were assessed using Kaplan-Meier estimates, and logistic regression identified factors associated with specific failure patterns.
Results:
Among 62 eligible patients (36 SCC, 26 ONB; median follow-up 44 months), ENI was associated with a lower nodal recurrence rate (4.8% vs. 34.1%; OR 0.10, p = 0.030) but not with overall or recurrence-free survival (p > 0.05). Perineural invasion was independently associated with worse recurrence-free survival. The association between ENI and reduced nodal recurrence appeared more pronounced in ONB.
Conclusions:
Despite the small sample size, ENI was associated with reduced nodal recurrence but not with improved survival in cN0 sinonasal SCC and ONB.
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