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Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

427
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
305
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

843
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
843
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

465
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
465
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

354
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
354
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

417
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
417

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Potential Risk Factors and Therapeutic Targets for Dilated Cardiomyopathy Identified Through Mendelian Randomization

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Journal of the American Heart Association
|December 30, 2025
PubMed
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Metabolic and lifestyle factors like blood pressure, BMI, and smoking influence dilated cardiomyopathy (DCM) risk. Identifying these factors and genetic targets may lead to new therapeutic strategies for DCM.

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Area of Science:

  • Cardiovascular Genetics
  • Metabolic Syndrome
  • Genetic Epidemiology

Background:

  • Dilated cardiomyopathy (DCM) is a serious heart condition.
  • Understanding metabolic and lifestyle influences is crucial for DCM management.
  • Identifying novel therapeutic targets is a key research objective.

Purpose of the Study:

  • To investigate the impact of metabolic and lifestyle factors on DCM.
  • To identify potential genetic variants and therapeutic targets for DCM.

Main Methods:

  • Bidirectional Mendelian randomization (MR) and Bayesian colocalization analyses were performed.
  • Utilized large-scale genome-wide association study data and the FinnGen project.
  • Employed various MR methods for robustness and summary-data-based MR for drug target analysis.

Main Results:

  • Genetically predicted systolic blood pressure, hypertension, BMI, and waist/hip circumference increased DCM risk.
  • Sleep duration and never smoking were identified as protective factors against DCM.
  • Eleven candidate genetic variants and risk genes, including SEMA7A and TGM2, were associated with DCM risk.

Conclusions:

  • Confirmed independent causal roles for systolic blood pressure, hypertension, BMI, waist/hip circumference, basal metabolic rate, sleep duration, and never smoking in DCM.
  • Identified several potential candidate variants and risk genes implicated in the genetic basis of DCM.