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Updated: Jan 7, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Design, synthesis, and antibacterial evaluation of novel thiosemicarbazone derivatives from estragole
Achraf Abdou1, Fatima Ezzahra Maaghloud1, Said Rammali2,3
1Laboratory of Organic Chemistry, Materials, Electrochemistry, and Environment, Faculty of Sciences Ain Chock, Hassan II University, Casablanca, Morocco.
Abstract:
Estragole (p-allylanisole) is a phenylpropene compound found in several aromatic plants and commonly extracted from the essential oil of fennel (Foeniculum vulgare Mill.). This study aimed to synthesise new chalcone derivatives from estragole to explore potential antimicrobial and antioxidant agents. Estragole was oxidised with potassium permanganate (KMnO4) to yield its corresponding aldehyde, acid, and diol derivatives. The aldehyde derivative was further reacted with thiosemicarbazide to form two chalcone-based thiosemicarbazone derivatives. These synthesised compounds are proposed to possess enhanced bioactive properties, suggesting their potential as new bioactive agents.
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