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Inhibition of Mandelate Racemase by Boron-Based Inhibitors: Different Binding Modes for Benzoxaboroles Versus Boronic

Joshua A Hayden1, Anika Jabin2, Oliver P Kuehm1

  • 1Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.

Biochemistry
|December 30, 2025
PubMed
Summary

Mandelate racemase (MR) enzyme activity can be inhibited by various boronic acid derivatives. Structure-activity studies reveal potent inhibition by naphthyl-, furan-, and thiophene-boronic acids, and benzoxaboroles like tavaborole.

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