Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame Topic

Bilateral Combined Retinal Vasculitis With Multiple Cotton Wool Spot-Like Lesions.

Ophthalmic surgery, lasers & imaging retina·2026
Same author

Cuticular drusen: a case report with 20-year follow up.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2026
Same author

The clinical importance of phenotyping drusen.

Indian journal of ophthalmology·2026
Same author

Delayed-onset cytomegalovirus retinitis after 0.2 µg/day fluocinolone acetonide implantation: a case series.

Journal of ophthalmic inflammation and infection·2026
Same author

Occlusive retinal vasculopathy on ultrawide-field fluorescein angiography in intraocular cytomegalovirus infection: a case series.

Journal of ophthalmic inflammation and infection·2026
Same author

Presumed enterovirus-associated bilateral asymmetrical retinitis with haemorrhagic occlusive retinal vasculitis secondary to hand, foot and mouth disease.

BMJ case reports·2026

Related Experiment Video

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

Acute Aggressive Posterior Progressive Necrotising Retinitis: Re-Evaluating Progressive Outer Retinal Necrosis.

Akshita Aggarwal1,2, Spoorti Mandadi2,3, Avinash Pathengay4

  • 1Standard Chartered - Academy for Eye Care Education, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, India.

Seminars in Ophthalmology
|December 30, 2025
PubMed
Summary

Progressive Outer Retinal Necrosis (PORN) involves inner retinal changes before outer retinal necrosis, challenging the condition's name. Optical Coherence Tomography (OCT) findings suggest a new, more accurate term is needed.

Keywords:
HIV retinopathyinflammationnecrotising retinitisoptical coherence tomographyprogressive outer retinal necrosis

More Related Videos

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
14:54

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy

Published on: November 29, 2015

9.0K
Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

4.3K

Related Experiment Videos

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
14:54

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy

Published on: November 29, 2015

9.0K
Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

4.3K

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Medical Imaging

Background:

  • Progressive Outer Retinal Necrosis (PORN) is a severe retinal condition primarily affecting immunocompromised individuals.
  • Accurate terminology is crucial for understanding disease progression and guiding treatment.

Purpose of the Study:

  • To analyze retinal involvement and Optical Coherence Tomography (OCT) findings in PORN.
  • To re-evaluate the terminology used for PORN based on observed pathophysiology.

Main Methods:

  • Retrospective review of 26 eyes from 15 HIV-positive patients diagnosed with PORN.
  • Analysis of clinical features, retinal fundus photography, and serial OCT images.
  • Exclusion of cases with media opacities.

Main Results:

  • OCT revealed inner retinal thickening and hyperreflectivity in most cases, which resolved over time.
  • Outer retinal layers were initially intact but showed necrosis in advanced stages.
  • Evidence indicates inner retinal involvement precedes outer retinal necrosis.

Conclusions:

  • The term "Progressive Outer Retinal Necrosis" (PORN) appears to be a misnomer based on OCT and histopathological findings.
  • "Acute Aggressive Posterior Progressive Necrotising Retinitis" is proposed as a more accurate descriptor of the disease's inner-to-outer retinal progression.