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Related Concept Videos

Secondary Active Transport01:55

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
Secondary Active Transport01:32

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
Insertion of Multi-pass Transmembrane Proteins in the RER01:29

Insertion of Multi-pass Transmembrane Proteins in the RER

The rough ER membrane synthesizes, assembles, and embeds transmembrane proteins in diverse topologies. These proteins function as transporters or channels and can remain in the ER membrane or are sent to the Golgi complex, lysosome, and cell membrane.
The multipass transmembrane proteins are the type IV integral membrane proteins with multiple topogenic sequences determining their spatial arrangement in the ER membrane. Nearly all multipass proteins lack a cleavable signal sequence and use...
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and produces two-second...
Secondary Active Transport01:32

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
Capillary Exchange01:28

Capillary Exchange

The cardiovascular system's chief role is to disseminate gases, nutrients, waste, and other substances to the body's cells. Small molecules like gases, lipids, and lipid-soluble substances directly diffuse through capillary wall endothelial cell membranes. Glucose, amino acids, and ions, including sodium, potassium, calcium, and chloride, use transporters for facilitated diffusion via membrane-specific channels. Glucose, ions, and bigger molecules may also pass through intercellular clefts.

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A Dual Domain Collaborative Network for Polyp Segmentation.

Yao Tong, Zuojian Zhou, Kongfa Hu

    IEEE Journal of Biomedical and Health Informatics
    |December 30, 2025
    PubMed
    Summary
    This summary is machine-generated.

    Accurate colorectal cancer detection relies on precise polyp segmentation in colonoscopy images. A new dual domain collaborative network (DDCNet) enhances boundary features and cross-level representations, significantly improving segmentation accuracy.

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    Area of Science:

    • Medical Imaging
    • Computer Vision
    • Artificial Intelligence

    Background:

    • Accurate polyp segmentation in colonoscopy is crucial for early colorectal cancer detection.
    • Existing methods struggle with indistinct boundaries and scale variations, limiting segmentation accuracy.

    Purpose of the Study:

    • To introduce a novel dual domain collaborative network (DDCNet) for improved polyp segmentation.
    • To address limitations in boundary feature optimization and cross-level representation alignment.

    Main Methods:

    • Developed a frequency context enhancement module (FCEM) for refining frequency domain features.
    • Introduced a cross-level shift recalibrated fusion module (CSFM) for spatial domain feature alignment.
    • Designed a hybrid loss function combining boundary, cross-entropy, and frequency consistency losses.

    Main Results:

    • DDCNet achieved state-of-the-art performance on three benchmark datasets (Kvasir SEG, CVC-ClinicDB, CVC-ColonDB).
    • Achieved Dice coefficients of 0.9343, 0.9447, and 0.8155, surpassing existing methods by 1.0%-1.5%.
    • Ablation studies confirmed the effectiveness of FCEM, CSFM, and the hybrid loss function.

    Conclusions:

    • DDCNet effectively improves polyp segmentation accuracy by enhancing boundary features and cross-level alignment.
    • The proposed method offers a significant advancement for automated polyp detection in colonoscopy.
    • The hybrid loss function and novel modules contribute to superior segmentation performance.