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Aluminium adjuvants and childhood health: a call for science

Guillemette Crépeaux1, Jeremy R Hammond2, Jonathan B Handley3

  • 1Univ Paris Est Créteil, INSERM, IMRB, Créteil F-94010, France; Ecole Nationale Vétérinaire d'Alfort, EnvA, IMRB, Maisons-Alfort F-94700, France.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|December 30, 2025
PubMed

Insights

Early-life exposure to Aluminium (Al)-adjuvanted vaccines showed no increased risk for 50 chronic diseases in a large Danish study. However, critical flaws in methodology and transparency raise concerns about the study's conclusions on Al-Based Adjuvant safety.

Area of Science:

  • Vaccine Adjuvant Safety
  • Toxicology
  • Epidemiology

Background:

  • Aluminium (Al)-based adjuvants (ABA) are widely used in vaccines.
  • Concerns persist regarding potential long-term health effects of ABA exposure.
  • A recent study by Andersson et al. (2025) investigated ABA safety in a large cohort.

Purpose of the Study:

  • To critically evaluate the methodological rigor and conceptual underpinnings of the Andersson et al. (2025) study on ABA safety.
  • To assess the validity of conclusions drawn regarding the association between early-life ABA exposure and chronic disease risk.

Main Methods:

  • Critical review of the methodology employed in the Andersson et al. (2025) study.
  • Analysis of cohort design, statistical analysis, and reporting of potential conflicts of interest.
  • Evaluation of the study's understanding of Aluminium toxicology.

Main Results:

  • The Andersson et al. (2025) study reported no association between early-life ABA exposure and 50 chronic diseases.
  • Significant methodological and conceptual flaws were identified in the study.
  • Weaknesses include limited toxicological understanding, cohort design issues, and insufficient transparency.

Conclusions:

  • The identified flaws prevent definitive conclusions on ABA safety, especially concerning neurodevelopmental and autoimmune outcomes.
  • The study's findings are not sufficiently robust to be considered reassuring evidence of ABA safety.
  • There is a critical need for more rigorous, transparent, and scientifically sound research on ABA safety.

Keywords:
Aluminium-Based AdjuvantsAutoimmune diseasesEpidemiologyMethodological flawsNeurodevelopmental outcomesVaccine safety

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