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Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
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Transcatheter Aortic Valve Replacement for Aortic Regurgitation: A Case-Based Review

Lucas Uchoa de Assis1, Andrea Mariani2, Antigone Kostea1

  • 1Department of Cardiology, Thoraxcenter, Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

The American Journal of Cardiology
|December 30, 2025
PubMed

Insights

Transcatheter aortic valve replacement (TAVR) offers a less invasive option for aortic regurgitation (AR) when surgery is high-risk. Dedicated devices show promise, but further research and device improvements are needed for wider TAVR adoption in AR treatment.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Valvular Heart Disease

Background:

  • Aortic regurgitation (AR) is a common valvular heart disease, increasing with age.
  • Surgical aortic valve replacement is standard but often deferred due to high surgical risk, leaving many severe AR patients untreated.
  • Transcatheter aortic valve replacement (TAVR) is a less invasive alternative, but off-label use faces challenges.

Purpose of the Study:

  • To review the evolving role of TAVR in treating aortic regurgitation.
  • To highlight practical considerations for TAVR in AR using patient vignettes.
  • To discuss device selection, anchoring, and complication management in TAVR for AR.

Main Methods:

  • Case-based review utilizing three patient vignettes.
  • Discussion of device selection and anchoring strategies for TAVR in AR.
  • Exploration of complication management in TAVR for AR.

Main Results:

  • Dedicated TAVR devices have improved procedural success for AR by addressing anchoring difficulties.
  • Patient vignettes illustrate key considerations in TAVR for AR.
  • Outcomes with dedicated TAVR systems for AR are encouraging.

Conclusions:

  • TAVR is an evolving treatment option for aortic regurgitation, particularly in high-risk patients.
  • Dedicated TAVR devices demonstrate improved efficacy and safety for AR.
  • Further research and device innovation are necessary to establish TAVR as a standard treatment for AR and improve patient outcomes.

Keywords:
Aortic regurgitationDevice embolizationPacemaker implantationTranscatheter aortic valve replacement

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