Real-time Capacity Reactance-based Innovative Technology for Detecting Malignant Cells: An Experimental...

Area of Science:

• Biophysics
• Medical Diagnostics
• Oncology

Background:

• Early cancer detection is crucial for effective treatment.
• Histopathology is the gold standard but lacks real-time capability.
• Novel screening methods are needed for real-time neoplastic cell identification.

Purpose of the Study:

• To introduce a novel medical diagnostic device for real-time cancer screening.
• To demonstrate the device's potential in detecting neoplastic/malignant lesions.
• To evaluate the device's efficacy as an early cancer detection tool.

Main Methods:

• A cohort of 215 patients was studied.
• Dielectric spectroscopy and equivalent electric circuit modeling were employed.
• Measurements of tissue impedance and capacitive reactance (θ angle) were collected from head and neck lesions.

Main Results:

• The θ angle measurements showed statistically significant differences between normal, non-neoplastic, and malignant tissues (p<0.001).
• Increased capacitive reactance contribution indicated the presence of neoplastic cells.
• The device provided reliable real-time detection of neoplastic cells.

Conclusions:

• Cancerous cells can be distinguished from healthy cells by measuring changes in capacitive reactance (θ angle).
• The developed medical device offers a reliable method for real-time early detection of neoplastic cells.
• This technology has potential as an innovative screening test for various neoplastic lesions.